mercoledì 25 maggio 2016

Tossicità da Solanina

Articolo originale, in inglese del Dott. Lebowitz sulla tossicità della solanina, tossina alimentare contenuta nel: Pomodoro, Peperone, Melanzane, Paprika, Pepe nero, Patate, Peperoncino, Goji, Ashwaganda. Tale tossina, che è utilizzata naturalmente dalle piante per difendersi dagli insetti è tossica nell'uomo. Diversi studi hanno dimostrato la correlazione tra la tossina è difetti di assorbimento di vitamina D e calcio, quindi relati a fenomeni osteo-degenerativi.
Qui di seguito l'articolo.

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SOLANINE TOXICITY SYNDROME

For over six months I have been studying and applying a new technique that has helped quite a number of chronic patients. Personally it has greatly increased my hip range of motion (much more so than great weekly AK treatments and other forms of bodywork), as well as eliminating some chronic knee and SI pain I have had. On other patients, it has eliminated post surgical wrist swelling in one, greatly decreased disabling shoulder and neck pain in another (this pain was unresponsive to multiple surgical interventions), chronic bilateral knee pain scheduled for 2 surgeries was eliminated, a juvenile RA patient became asymptomatic, etc. The results have been exciting but in some ways I think the results are even better in asymptomatic patients as it can help prevent arteriosclerosis, osteoporosis and many other conditions in certain patients (though of course you can’t prove that).

In muscle testing we are only as good as taking a great history, knowing what to test and how to interpret the test, testing accurately and without bias, having top quality test vials (if applicable), and top quality therapeutic remedies (if applicable). In this case I was partially aware academically of these phenomena but unable to find the problem with AK (and worse, I thought I could find it, but in reality was missing it 90% of the time).

I am going to call this condition SOLANINE TOXICITY SYNDROME (STS). In this issue of the newsletter we will cover some of the basic

academics while in the July issue we will cover diagnosis and treatment. STS appears to affect about 1/3rdof the chronic patient load of my practice and other doctors of whom I have shared with this technique. Alpha-solanine is a glycol-alkaloid found in the nightshade family of plants. The ones that might practically affect us (much of this family we do not eat) are in tomatoes, potatoes, eggplant, peppers, paprika, tobacco, gogi berries, and ashwagandha. The amount of solanine present in the above vary tremendously depending on growing conditions, time harvested, storage conditions, cooking techniques, etc. Much of the academic work can be creditied to Dr. Norman Childers who has been researching nightshades for about 50 years, especially in farm animals.

Historically most solanine containing foods were not considered edibles before the 1800’s (except in some parts of South America). Even foods like kim-chee did not have peppers in them 100 years ago but just utilized a salt brine. Solanine containing foods were mainly used for witchcraft a few hundred years ago, not regular ingestion. Now it is rare people go a day or even a meal without some form of tomatoes, potatoes, peppers, etc. Solanines are not water soluble, are not destroyed by cooking and are not broken down inside the body but must be excreted as alpha-solanine.

Different people have different degrees of sensitivity to them, and different efficiencies in being able to excrete them. How or in what way they will affect you will be a matter of genetics, as well as lifestyle and nutritional status. If you test positive for this problem, the probability is very high that at least 50% of your blood relatives may have it too, to varying degrees.

The average daily intake of alpha-solanine is approximately 13mg and the average daily excretion is 5% the first day and 1-2% daily thereafter with a half-life of about 1-2 months. Considering that is for one day’s dose, it is estimated that the average body burden is at least 50mg. It can be much higher in people like myself who have a history of pouring salsa on about everything they eat. Alpha-solanine is stored in most organs (with a special affinity for the thyroid gland) as well as most soft tissue including skeletal muscle.

Alpha-solanine is classified as a neuro-toxin. Interestingly most “foods” that contain alpha-solanine also contain at least 5 other neurotoxins including atropine and nicotine. Acute solanine poisoning can happen from ingesting green or sprouted potatoes or green tomatoes with symptoms including cramps, diarrhea, dizziness and sleepiness.

We are more concerned with “chronic poisoning”, what we are calling STS. Solanine acts as an acetyl cholinesterase inhibitor (similar to Malathion, Parathion and other “nerve gases”) allowing acetylcholine to build up in the synapses.

On a practical level it can do the following in sensitive patients; 1) act as an endocrine disruptor especially to the thyroid, 2) cause chronic joint pain, arthritis (all forms), joint inflammation- this is due to solanines ability to remove calcium from the bones and deposit it in any weak or genetically predisposed area of the body, 3) for the same reason it can be a major contributor to osteoporosis (since it removes calcium from the bones) and arteriosclerosis (it can deposit the calcium in the blood vessels), 4) “leaky gut” as well as IBS,

5) appendicitis, 6) birth defects including spina bifida, 7) depression (correcting it in one patient stopped their strong suicidal tendencies), 8) migraines, 9) can greatly interfere with calcium and vitamin D absorption, despite supplementation.